hrp0092p1-47 | Fat, Metabolism and Obesity | ESPE2019

How Early is 'extreme Early-Onset Obesity'? Results of Comprehensive Growth Curve Analysis to Identify Genetic Obesity Disorders Based on Age of Onset of Obesity

Abawi Ozair , Kleinendorst Lotte , Blankers Lizette , van Haelst Mieke , van der Voorn Bibian , van den Akker Erica

Background: Early-onset obesity is associated with genetic obesity disorders. According to the Endocrine Society guideline for paediatric obesity, genetic screening is indicated in selected cases with age of onset (AoO) of obesity <5 years. However, this cut-off value lacks evidence. Identifying genetic obesity is vital as treatment for leptin-melanocortin pathway disorders becomes available. We aimed to determine whether AoO of obesity is predictive for g...